European explorers found sanctuary in the bountiful lands of the Southeast centuries ago. Now, these tranquil waterways offer guests an exploration of history and natural beauty with cruises along the Intracoastal Waterway and Inland Passage routes of the East Coast.
American Cruise Lines offers the best Southeast U.S. cruises featuring the early American ideal on our Chesapeake Bay cruises, Southern hospitality on our scenic Southeast Sea Islands cruise, and the sun-kissed treasures of the Florida Gulf Coast.
Our East Coast small ship cruise itineraries bring guests to unique, historic, and bucket-list destinations such as Colonial Williamsburg, Washington, D.C.; Annapolis, MD; Baltimore, MD; Charleston, SC; Amelia Island, FL; St. Augustine, FL; St. Petersburg, FL; and Key West, FL.